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A comparison of the effects of desflurane, sevoflurane and propofol on QT, QTc, and P dispersion on ECG


1 Turkey Yuksek Ihtisas Hospital Anaestesiology and Reanimation Clinic, Turkey
2 Ankara Atatürk Education and Research Hospital Anaestesiology and Reanimation Clinic, Turkey
3 Gaziantep Universty Hospital Anaestesiology and Reanimation Clinic, Turkey
4 Sivas Cumhuriyet Universty Cardiology Clinic, Turkey

Correspondence Address:
Dilek Kazanci
Yasamkent Mah. 3222/1 sokak Armoni sitesi 3. Blok Daire: 5 Yenimahalle/ANKARA
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-9784.51361

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Year : 2009  |  Volume : 12  |  Issue : 2  |  Page : 107-112

 

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The aim of this prospective, randomized, and double-blinded study was to compare the effects of desflurane, sevoflurane, propofol on both atrial and ventricular wall function by measurement of QT dispersion (QTd), corrected QT dispersion (QTcd), and P dispersion (Pd) on electrocardiogram (ECG). Forty-six patients from the American Society of Anesthesiologists class I−II undergoing noncardiac surgery, were enrolled in this study. Patients were randomly allocated to receive desflurane, sevoflurane or propofol anesthesia. ECG recordings were taken before and after 5 minutes of drug administration. Induction with desflurane significantly increased the QTd compared to baseline (38 ± 2 ms vs. 62 ± 6 ms, P < 0.05). Sevoflurane and propofol anesthesia was not associated with any changes in QTd. QTcd was increased with desflurane induction and decreased with sevoflurane and propofol induction, but this decrease was only significant in the propofol group (67 ± 5 ms vs. 45 ± 3 ms, P < 0.05). Pd was significantly increased after induction with desflurane (34 ± 3 vs. 63 ± 6 ms, P < 0.05). There was a significant increase in QTd and Pd in desflurane group, but this increment did not cause any dangerous arrhythmias. QTcd significantly decreased in propofol group. We believe that further investigations are required for using desflurane as safe as sevoflurane and propofol in noncardiac surgery patients who have high cardiac arrhythmia and ischemia risk.






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1 Turkey Yuksek Ihtisas Hospital Anaestesiology and Reanimation Clinic, Turkey
2 Ankara Atatürk Education and Research Hospital Anaestesiology and Reanimation Clinic, Turkey
3 Gaziantep Universty Hospital Anaestesiology and Reanimation Clinic, Turkey
4 Sivas Cumhuriyet Universty Cardiology Clinic, Turkey

Correspondence Address:
Dilek Kazanci
Yasamkent Mah. 3222/1 sokak Armoni sitesi 3. Blok Daire: 5 Yenimahalle/ANKARA
Turkey
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-9784.51361

Rights and Permissions

The aim of this prospective, randomized, and double-blinded study was to compare the effects of desflurane, sevoflurane, propofol on both atrial and ventricular wall function by measurement of QT dispersion (QTd), corrected QT dispersion (QTcd), and P dispersion (Pd) on electrocardiogram (ECG). Forty-six patients from the American Society of Anesthesiologists class I−II undergoing noncardiac surgery, were enrolled in this study. Patients were randomly allocated to receive desflurane, sevoflurane or propofol anesthesia. ECG recordings were taken before and after 5 minutes of drug administration. Induction with desflurane significantly increased the QTd compared to baseline (38 ± 2 ms vs. 62 ± 6 ms, P < 0.05). Sevoflurane and propofol anesthesia was not associated with any changes in QTd. QTcd was increased with desflurane induction and decreased with sevoflurane and propofol induction, but this decrease was only significant in the propofol group (67 ± 5 ms vs. 45 ± 3 ms, P < 0.05). Pd was significantly increased after induction with desflurane (34 ± 3 vs. 63 ± 6 ms, P < 0.05). There was a significant increase in QTd and Pd in desflurane group, but this increment did not cause any dangerous arrhythmias. QTcd significantly decreased in propofol group. We believe that further investigations are required for using desflurane as safe as sevoflurane and propofol in noncardiac surgery patients who have high cardiac arrhythmia and ischemia risk.






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