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Brugada syndrome and its relevance in the perioperative period


Department of Anesthesiology, Mayo Clinic, Arizona, AZ 85259, USA

Correspondence Address:
Farouk Mookadam
Division of Cardiovascular Diseases, Mayo Clinic Arizona, 13400, East Shea Boulevard, Scottsdale, AZ 85259
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-9784.159812

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Year : 2015  |  Volume : 18  |  Issue : 3  |  Page : 403-413

 

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Brugada syndrome is an autosomal dominant genetic disorder associated with an increased risk of sudden cardiac death, as well as ventricular tachyarrhythmias.The defective cardiac sodium channels result in usual electrocardiographic findings of a coved-type ST elevation in precordial leads V1 to V3. The majority of patients have uncomplicated courses with anesthesia, surgery, and invasive procedures. However there is risk of worsening ST elevation and ventricular arrhythmias due to perioperative medications, surgical insult, electrolyte abnormalities, fever, autonomic nervous system tone, as well as other perturbations. Given the increasing numbers of patients with inherited conduction disorders presenting for non-cardiac surgery that are at risk of sudden cardiac death, safe anesthetic management depends upon a detailed knowledge of these conditions.






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Department of Anesthesiology, Mayo Clinic, Arizona, AZ 85259, USA

Correspondence Address:
Farouk Mookadam
Division of Cardiovascular Diseases, Mayo Clinic Arizona, 13400, East Shea Boulevard, Scottsdale, AZ 85259
USA
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-9784.159812

Rights and Permissions

Brugada syndrome is an autosomal dominant genetic disorder associated with an increased risk of sudden cardiac death, as well as ventricular tachyarrhythmias.The defective cardiac sodium channels result in usual electrocardiographic findings of a coved-type ST elevation in precordial leads V1 to V3. The majority of patients have uncomplicated courses with anesthesia, surgery, and invasive procedures. However there is risk of worsening ST elevation and ventricular arrhythmias due to perioperative medications, surgical insult, electrolyte abnormalities, fever, autonomic nervous system tone, as well as other perturbations. Given the increasing numbers of patients with inherited conduction disorders presenting for non-cardiac surgery that are at risk of sudden cardiac death, safe anesthetic management depends upon a detailed knowledge of these conditions.






[FULL TEXT] [PDF]*


        
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