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Table of Contents
LETTERS TO EDITOR  
Year : 2021  |  Volume : 24  |  Issue : 4  |  Page : 515-516
In response to describing right ventricular dysfunction: Diagnostic accuracy studies and sources of bias


Department of Cardiac Anaesthesiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Jayanagar, Bangalore, Karnataka, India

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Date of Submission26-Jun-2020
Date of Acceptance08-Aug-2020
Date of Web Publication18-Oct-2021
 

How to cite this article:
Singh NG, Kumar KN, Nagaraja P S, Manjunatha N. In response to describing right ventricular dysfunction: Diagnostic accuracy studies and sources of bias. Ann Card Anaesth 2021;24:515-6

How to cite this URL:
Singh NG, Kumar KN, Nagaraja P S, Manjunatha N. In response to describing right ventricular dysfunction: Diagnostic accuracy studies and sources of bias. Ann Card Anaesth [serial online] 2021 [cited 2021 Nov 30];24:515-6. Available from: https://www.annals.in/text.asp?2021/24/4/515/328492




To the Editor,

Thangaswamy and colleagues[1] in their letter have stated that the limitations in our study , Portal venous pulsatility fraction, a novel transesophageal echocardiographic marker for right ventricular dysfunction in cardiac surgical patients'.[2] relate to spectrum or selection bias, lack ofrater blinding, and limited working definition of positive and negative test results. The issues outlined indicate some latent biases accompanying the clinical special tests and their diagnostic accuracy, in this case, the portal venous pulsatility fraction (PF), that the authors have undertaken.

The reply by the authors for the letter is as follows: The authors have missed to mention the spectrum of cases; however, it was specified during the review process of the manuscript. There were a total of 27 patients included in the study of which 3 patients had coronary artery disease (CAD), 1 patient had CAD with aortic stenosis, 5 patients had severe Mitral regurgitation, 3 patients with severe aortic regurgitation, 4 patients with severe aortic stenosis, 9 patients with severe mitral stenosis, and 2 patients had (atrial septal defect) ASD. The possibility of spectrum bias could be observed only when most of the patients suffered from mitral valve stenosis which was not true in the present study.

Second, regarding rater blinding, right ventricle (RV) dysfunction was classified based on Tricuspid annular plane systolic excursion (TAPSE) (<15 mm), RV Fractional Area change (FAC) (<35%), and RV Ejection Fraction (EF) (<45%) parameters. If at least two parameters of the three were positive, it was deemed as RV dysfunction. Post comprehensive tranesophageal echocardiography (TEE) examination, above RV parameters and corresponding PF of portal vein were assessed. The echocardiographer performing the TEE was not aware of the normal PF and its significance in RV dysfunction patients. However, previous studies have shown a wide range of abnormal PF values, i.e. Shih et al.[3] 43% to 194% and Denault et al.[4] 51% to 100%. Cut off value of PF >45% was obtained only after computing both normal and abnormal values of RV function parameters with their corresponding PF of portal vein, at the end of the study by constructing ROC curves.

Lastly, to answer their final query, PF >45% had a sensitivity of 92.3%, specificity of 71.4%, positive predictive value of 75%, and negative predictive value of 90.9% for RV dysfunction. The present study had 13 patients (48.15%) with RV dysfunction. PF values quoted by Thangaswamy et al.[1] regarding Shih et al.[3] and Denault et al.[4] of 87.8% and 75.35%, respectively, represent only mean values and not the cut off values. This is to reiterate that cut off values are obtained by constructing Receiver Operating Characteristic (ROC) curve unlike mean values. In addition, in the above studies, RV dysfunction was classified based on the CVP.[3] In the present study, the more reliable echocardiographic parameters were assessed for RV dysfunction. Shih et al.[3] also report that PF >40% signifies RV dysfunction which is similar to the present study.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Thangaswamy CR, Sundararaj R, Parida S, Jha AK. Describing right ventricular dysfunction: Diagnostic accuracy studies and sources of bias. 2020;24:513-4.  Back to cited text no. 1
    
2.
Singh NG, Kumar KN, Nagaraja PS, Manjunatha N. Portal venous pulsatility fraction, a novel transesophageal echocardiographic marker for right ventricular dysfunction in cardiac surgical patients. Ann Card Anaesth 2020;23:39-42.  Back to cited text no. 2
[PUBMED]  [Full text]  
3.
Shih CY, Yang SS, Hu JT, Lin CL, Lai YC, Chang CW. Portal vein pulsatility index is a more important indicator than congestion index in the clinical evaluation of right heart function. World J Gastroenterol 2006;12:768-71.  Back to cited text no. 3
    
4.
Denault AY, Beaubien-Souligny W, Elmi-Sarabi M, Eljaiek R, El-Hamamsy I, Lamarche Y, et al. Clinical significance of portal hypertension diagnosed with bedside ultrasound after cardiac surgery. Anesth Analg 2017;124:1109-15.  Back to cited text no. 4
    

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Correspondence Address:
Karthik Narendra Kumar
Department of Cardiac Anaesthesia, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore - 560 069, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/aca.ACA_148_20

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