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Outcomes following the use of angiotensin II in patients with postoperative vasoplegic syndrome: A case series


1 Department of Internal Medicine, University of Virginia Health, Charlottesville, VA, USA
2 Department of Pharmacy, University of Virginia Health, Charlottesville, VA, USA
3 Department of Anesthesiology and Critical Care Medicine, University of Virginia Health, Charlottesville, VA, USA
4 Department of Pulmonary and Critical Care Medicine, University of Virginia Health, Charlottesville, VA, USA

Correspondence Address:
Andrew D Mihalek
1215 Lee St. Charlottesville, VA 22903
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/aca.aca_98_21

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Year : 2022  |  Volume : 25  |  Issue : 3  |  Page : 359-361

 

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Catecholamine-resistant postoperative vasoplegic syndrome (PVS) lacks effective treatment modalities. Synthetic angiotensin II was recently approved for the treatment of vasodilatory shock; however, its use in PVS is not well described. We report outcomes in six patients receiving angiotensin II for the treatment of isolated PVS. All patients achieved their MAP goal and the majority showed improvement in lactate and background catecholamine dose; however, variables of perfusion changed discordantly. Three of six patients survived to hospital discharge.






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1 Department of Internal Medicine, University of Virginia Health, Charlottesville, VA, USA
2 Department of Pharmacy, University of Virginia Health, Charlottesville, VA, USA
3 Department of Anesthesiology and Critical Care Medicine, University of Virginia Health, Charlottesville, VA, USA
4 Department of Pulmonary and Critical Care Medicine, University of Virginia Health, Charlottesville, VA, USA

Correspondence Address:
Andrew D Mihalek
1215 Lee St. Charlottesville, VA 22903
USA
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/aca.aca_98_21

Rights and Permissions

Catecholamine-resistant postoperative vasoplegic syndrome (PVS) lacks effective treatment modalities. Synthetic angiotensin II was recently approved for the treatment of vasodilatory shock; however, its use in PVS is not well described. We report outcomes in six patients receiving angiotensin II for the treatment of isolated PVS. All patients achieved their MAP goal and the majority showed improvement in lactate and background catecholamine dose; however, variables of perfusion changed discordantly. Three of six patients survived to hospital discharge.






[FULL TEXT] [PDF]*


        
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