Pierre Fricault1, Juliette Piot1, Cécile Estève1, Veaceslav Savan1, Alexandre Sebesteyn2, Michel Durand1, Olivier Chavanon2, Pierre Albaladejo1
1 Department of Anesthesiology and Critical Care, University Hospital, Grenoble, France
2 Department of Cardiac Surgery, University Hospital, Grenoble, France
Background: High preoperative fibrinogen levels are associated with reduced bleeding rates after cardiac surgery. Fibrinogen is directly involved in inflammatory processes and is a cardiovascular risk factors. Whether high fibrinogen levels before cardiac surgery are a risk factor for mortality or morbidity remains unclear.
Aims: This study aimed to examine the association between preoperative fibrinogen levels and mortality and morbidity rates after cardiac surgery.
Settings and Design: This is a single-center retrospective study.
Material and Methods: Patients (n = 1628) were divided into high (HFGr) and normal (NFGr) fibrinogen level groups, based on the cutoff value of 3.3 g/L, derived from the receiver operating characteristic (ROC) curve analysis. The primary outcome was the 30-day mortality rate. The rates of postoperative complications, including postoperative bleeding and transfusion rates, were examined.
Statistical Analysis: Between-group comparisons were performed with the Mann–Whitney U test and Chi-squared test, as suitable. Model discriminative power was examined with the area under the ROC curve.
Results: The HFGr and NFGr included 1103 and 525 patients, respectively. Mortality rate was higher in the HFGr than in the NFGr (2.7% vs. 1.1%, P = 0.04). The 12-h bleeding volume (280 mL [195–400] vs. 305 mL [225–435], P = 0.0003) and 24-h bleeding volume values (400 mL [300–550] vs. 450 mL [340–620], P < 0.0001) were lower in the HFGr than in the NFGr. However, the rate of red blood cell transfusion during hospitalization was higher in the HFGr than in the NFGr (21.7% vs. 5.9%, P = 0.0103). Major complications were more frequent in the HFGr than in the NFGr.
Conclusion: High fibrinogen levels were associated with reduced postoperative bleeding volume and increased mortality and morbidity rates.
Pôle Anesthésie-Réanimation, Hopital Michallon, University Hospital Grenoble-Alpes, 38043 Grenoble Cedex 9
Source of Support: None, Conflict of Interest: None
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