Year : 2014  |  Volume : 17  |  Issue : 2  |  Page : 118--124

Hypertrophic cardiomyopathy: Part 1 - Introduction, pathology and pathophysiology


Praveen Kerala Varma1, Praveen Kumar Neema2 
1 Department of Cardiac Surgery, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India
2 Department of Anesthesiology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India

Correspondence Address:
Praveen Kerala Varma
Department of Cardiac Surgery, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum - 695 011, Kerala
India

Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiovascular disease with many genotype and phenotype variations. Earlier terminologies, hypertrophic obstructive cardiomyopathy and idiopathic hypertrophic sub-aortic stenosis are no longer used to describe this entity. Patients present with or without left ventricular outflow tract (LVOT) obstruction. Resting or provocative LVOT obstruction occurs in 70% of patients and is the most common cause of heart failure. The pathology and pathophysiology of HCM includes hypertrophy of the left ventricle with or without right ventricular hypertrophy, systolic anterior motion of mitral valve, dynamic and mechanical LVOT obstruction, mitral regurgitation, diastolic dysfunction, myocardial ischemia, and fibrosis. Thorough understanding of pathology and pathophysiology is important for anesthetic and surgical management.


How to cite this article:
Varma PK, Neema PK. Hypertrophic cardiomyopathy: Part 1 - Introduction, pathology and pathophysiology.Ann Card Anaesth 2014;17:118-124


How to cite this URL:
Varma PK, Neema PK. Hypertrophic cardiomyopathy: Part 1 - Introduction, pathology and pathophysiology. Ann Card Anaesth [serial online] 2014 [cited 2023 Feb 1 ];17:118-124
Available from: https://www.annals.in/article.asp?issn=0971-9784;year=2014;volume=17;issue=2;spage=118;epage=124;aulast=Varma;type=0